电邮这篇文章 Synuclein Deficiency Decreases the Efficiency of Dopamine Uptake by Synaptic Vesicles
- 作者: Ninkina N.N.1,2, Tarasova T.V.1,2, Chaprov K.D.1, Goloborshcheva V.V.1, Bachurin S.O.1, Buchman V.L.1,2
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隶属关系:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Cardiff University, School of Biosciences, Sir Martin Evans Building, Museum Avenue
- 期: 卷 486, 编号 1 (2019)
- 页面: 168-170
- 栏目: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212988
- DOI: https://doi.org/10.1134/S1607672919030025
- ID: 212988
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详细
In the present study, we analyzed the uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from the dorsal striatum of mice with constitutive inactivation of all three synuclein-coding genes and wild-type mice. Synuclein deficiency substantially compromised the uptake of this neurotransmitter by synaptic vesicles but had no effect on synaptosomal dopamine uptake.
作者简介
N. Ninkina
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
俄罗斯联邦, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
T. Tarasova
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
俄罗斯联邦, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
K. Chaprov
Institute of Physiologically Active Compounds,Russian Academy of Sciences
编辑信件的主要联系方式.
Email: chapkir@gmail.com
俄罗斯联邦, Chernogolovka,
Moscow oblast, 142432
V. Goloborshcheva
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: chapkir@gmail.com
俄罗斯联邦, Chernogolovka,
Moscow oblast, 142432
S. Bachurin
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: chapkir@gmail.com
俄罗斯联邦, Chernogolovka,
Moscow oblast, 142432
V. Buchman
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
俄罗斯联邦, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
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