Мақаланы E-mail арқылы жіберу Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins
- Авторлар: Lankin V.Z.1, Sharapov M.G.2, Goncharov R.G.2, Tikhaze A.K.1, Novoselov V.I.2
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Мекемелер:
- National Medical Research Center of Cardiology, Ministry of Healthcare of the Russian Federation
- Institute of Cell Biophysics, Russian Academy of Sciences
- Шығарылым: Том 485, № 1 (2019)
- Беттер: 132-134
- Бөлім: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212926
- DOI: https://doi.org/10.1134/S1607672919020157
- ID: 212926
Дәйексөз келтіру
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Рұқсат берілді
Тек жазылушылар үшін
Аннотация
It was established that recombinant human peroxiredoxins (Prx1, Prx2, Prx4, and Prx6) inhibit natural dicarbonyls formed during free radical peroxidation of unsaturated lipids (malonic dialdehyde) and oxidative transformations of glucose (glyoxal and methylglyoxal). A possible role of the decrease in the activity of peroxiredoxins under oxidative and carbonyl stress is discussed as an important factor that triggers the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus.
Авторлар туралы
V. Lankin
National Medical Research Center of Cardiology, Ministryof Healthcare of the Russian Federation
Хат алмасуға жауапты Автор.
Email: lankin941@mail.ru
Ресей, Moscow,
121552
M. Sharapov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
Ресей, Pushchino, Moscow oblast, 142290
R. Goncharov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
Ресей, Pushchino, Moscow oblast, 142290
A. Tikhaze
National Medical Research Center of Cardiology, Ministryof Healthcare of the Russian Federation
Email: lankin941@mail.ru
Ресей, Moscow,
121552
V. Novoselov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
Ресей, Pushchino, Moscow oblast, 142290
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