电邮这篇文章 Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins
- 作者: Lankin V.Z.1, Sharapov M.G.2, Goncharov R.G.2, Tikhaze A.K.1, Novoselov V.I.2
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隶属关系:
- National Medical Research Center of Cardiology, Ministry of Healthcare of the Russian Federation
- Institute of Cell Biophysics, Russian Academy of Sciences
- 期: 卷 485, 编号 1 (2019)
- 页面: 132-134
- 栏目: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212926
- DOI: https://doi.org/10.1134/S1607672919020157
- ID: 212926
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详细
It was established that recombinant human peroxiredoxins (Prx1, Prx2, Prx4, and Prx6) inhibit natural dicarbonyls formed during free radical peroxidation of unsaturated lipids (malonic dialdehyde) and oxidative transformations of glucose (glyoxal and methylglyoxal). A possible role of the decrease in the activity of peroxiredoxins under oxidative and carbonyl stress is discussed as an important factor that triggers the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus.
作者简介
V. Lankin
National Medical Research Center of Cardiology, Ministryof Healthcare of the Russian Federation
编辑信件的主要联系方式.
Email: lankin941@mail.ru
俄罗斯联邦, Moscow,
121552
M. Sharapov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
俄罗斯联邦, Pushchino, Moscow oblast, 142290
R. Goncharov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
俄罗斯联邦, Pushchino, Moscow oblast, 142290
A. Tikhaze
National Medical Research Center of Cardiology, Ministryof Healthcare of the Russian Federation
Email: lankin941@mail.ru
俄罗斯联邦, Moscow,
121552
V. Novoselov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
俄罗斯联邦, Pushchino, Moscow oblast, 142290
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