Enviar artigo por via de e-mail Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins
- Autores: Lankin V.Z.1, Sharapov M.G.2, Goncharov R.G.2, Tikhaze A.K.1, Novoselov V.I.2
-
Afiliações:
- National Medical Research Center of Cardiology, Ministry of Healthcare of the Russian Federation
- Institute of Cell Biophysics, Russian Academy of Sciences
- Edição: Volume 485, Nº 1 (2019)
- Páginas: 132-134
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212926
- DOI: https://doi.org/10.1134/S1607672919020157
- ID: 212926
Citar
Acesso aberto
Acesso está concedido
Somente assinantes
Resumo
It was established that recombinant human peroxiredoxins (Prx1, Prx2, Prx4, and Prx6) inhibit natural dicarbonyls formed during free radical peroxidation of unsaturated lipids (malonic dialdehyde) and oxidative transformations of glucose (glyoxal and methylglyoxal). A possible role of the decrease in the activity of peroxiredoxins under oxidative and carbonyl stress is discussed as an important factor that triggers the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus.
Sobre autores
V. Lankin
National Medical Research Center of Cardiology, Ministryof Healthcare of the Russian Federation
Autor responsável pela correspondência
Email: lankin941@mail.ru
Rússia, Moscow,
121552
M. Sharapov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
Rússia, Pushchino, Moscow oblast, 142290
R. Goncharov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
Rússia, Pushchino, Moscow oblast, 142290
A. Tikhaze
National Medical Research Center of Cardiology, Ministryof Healthcare of the Russian Federation
Email: lankin941@mail.ru
Rússia, Moscow,
121552
V. Novoselov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
Rússia, Pushchino, Moscow oblast, 142290
Arquivos suplementares
