Отправить статью по E-mail Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins
- Авторы: Lankin V.Z.1, Sharapov M.G.2, Goncharov R.G.2, Tikhaze A.K.1, Novoselov V.I.2
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Учреждения:
- National Medical Research Center of Cardiology, Ministry of Healthcare of the Russian Federation
- Institute of Cell Biophysics, Russian Academy of Sciences
- Выпуск: Том 485, № 1 (2019)
- Страницы: 132-134
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212926
- DOI: https://doi.org/10.1134/S1607672919020157
- ID: 212926
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Аннотация
It was established that recombinant human peroxiredoxins (Prx1, Prx2, Prx4, and Prx6) inhibit natural dicarbonyls formed during free radical peroxidation of unsaturated lipids (malonic dialdehyde) and oxidative transformations of glucose (glyoxal and methylglyoxal). A possible role of the decrease in the activity of peroxiredoxins under oxidative and carbonyl stress is discussed as an important factor that triggers the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus.
Об авторах
V. Lankin
National Medical Research Center of Cardiology, Ministryof Healthcare of the Russian Federation
Автор, ответственный за переписку.
Email: lankin941@mail.ru
Россия, Moscow,
121552
M. Sharapov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
Россия, Pushchino, Moscow oblast, 142290
R. Goncharov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
Россия, Pushchino, Moscow oblast, 142290
A. Tikhaze
National Medical Research Center of Cardiology, Ministryof Healthcare of the Russian Federation
Email: lankin941@mail.ru
Россия, Moscow,
121552
V. Novoselov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
Россия, Pushchino, Moscow oblast, 142290
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