Effectiveness of a novel hydrolysate collagen formulation in the complex treatment and rehabilitation of patients with symptomatic knee osteoarthritis

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Abstract

BACKGROUND: Knee osteoarthritis is a chronic disease that can eventually lead to surgical arthroplasty. Overuse, inflammation, metabolic disorders, and hormonal changes play important roles in the pathogenetic development of osteoarthritis of the knee. Recent studies have shown that collagen hydrolysate slows down the degenerative processes in cartilage tissue and has analgesic and anti-inflammatory effects.

AIMS: To examine the effect of a dietary supplement of collagen hydrolysate (COLLA GEN) on the treatment and rehabilitation of patients with symptomatic knee osteoarthritis.

MATERIALS AND METHODS: This prospective, blinded, placebo-controlled study included 99 patients diagnosed with radiographic knee osteoarthritis. All patients were randomly divided into two groups. Both groups were prescribed a course of therapeutic exercises. Group I was also prescribed a food supplement of collagen hydrolysate (COLLA GEN), whereas group II received placebo. The effectiveness of collagen hydrolysate in symptomatic osteoarthritis was evaluated based on the comparison of the WOMAC and VAS scores before the treatment and rehabilitation process and after 1, 3, and 6 months.

RESULTS: Daily intake of 40 g of collagen hydrolysate dietary supplement of collagen hydrolysate («COLLA GEN») for 3 months, in combination with exercise therapy, in patients with symptomatic osteoarthritis, allowed statistically significant (p <0.05), compared with the placebo group, to improve such indicators on the WOMAC scale as «pain» (3.9±1.5 in group I and 5.4±1.8 in group II), «physical function» (8.7±3.2 in group I and 13.7±2.9 in group II), and «total score» (14.5±5.2 in group I and 21.5±4.9 in group II) by 6 months of observation. When analyzing the indicators on the VAS scale at the end of the 3rd and 6th month of treatment, a statistically significant difference (p <0.05) was observed between the indicators of regression of pain symptoms, which were 2.17 and 3.72 points in group I and 0.83 and 2.03 points in group II, respectively.

CONCLUSION: The use of a novel hydrolysate collagen formulation in the complex treatment and rehabilitation of patients with symptomatic knee osteoarthritis has potential therapeutic effects.

About the authors

Aleksey D. Repetyuk

Sechenov First Moscow State Medical University

Author for correspondence.
Email: repetyuk_a_d@staff.sechenov.ru
ORCID iD: 0000-0003-0758-4590

md, cand. sci. (med.)

Russian Federation, Moscow

Konstantin S. Ternovoy

Sechenov First Moscow State Medical University

Email: ternovoy_k_s@staff.sechenov.ru
ORCID iD: 0000-0003-2378-8163

md, cand. sci. (med.)

Russian Federation, Moscow

References

  1. Safiri S, Kolahi AA, Smith E, et al. Global, regional and national burden of osteoarthritis 1990–2017: a systematic analysis of the Global Burden of Disease Study 2017. Ann Rheum Dis. 2020;79(6):819–828. doi: 10.1136/annrheumdis-2019-216515
  2. Novakov VB, Novakova ON, Churnosov MI. Risk factors and molecular entities of the etiopathogenesis of the knee osteoarthritis (literature review). Genij ortopedii. 2021;27(1):112–120. doi: 10.18019/1028-4427-2021-27-1-112-120
  3. Mazurov VI, Trofimova AS, Trofimov EA. Risk factors and some aspects of the osteoarthritis pathogenesis. Herald of the Northwestern State Medical University named after I.I. Mechnikov. 2016;8(2):116–124.
  4. Lisitsyna EM, Lisitsyn MP, Zaremuk AM. Modern approach to the understanding of pathogenesis, diagnosis and treatment of knee osteoarthrosis. Endoskopicheskaya khirurgiya. 2016;22(6):57–67. (In Russ). doi: 10.17116/endoskop201622657-67
  5. Geyer M, Schönfeld C. Novel insights into the pathogenesis of osteoarthritis. Curr Rheumatol Rev. 2018;14(2):98–107. doi: 10.2174/1573397113666170807122312
  6. Liu S, Yang H, Hu B, et al. Regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/β-catenin signaling pathways. Exp Ther Med. 2017;14(5):5057–5062. doi: 10.3892/etm.2017.5165
  7. Rezuş E, Burlui A, Cardoneanu A, et al. From pathogenesis to therapy in knee osteoarthritis: bench-to-bedside. Int J Mol Sci. 2021;22(5):2697. doi: 10.3390/ijms22052697
  8. Chow YY, Chin KY. The role of inflammation in the pathogenesis of osteoarthritis. Mediators Inflamm. 2020;2020:8293921. doi: 10.1155/2020/8293921
  9. Krawetz RJ, Wu YE, Bertram KL, et al. Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity. Cell Death Dis. 2022;13(5):470. doi: 10.1038/s41419-022-04919-1
  10. Gladkova EV, Mamonova IA, Ulyanov VY. Pathogenetic aspects of immune regulation of bone remodeling processes in the debut of primary osteoarthritis of knee joints. Bulletin of new medical technologies. 2022;29(3):63–66. (In Russ). doi: 10.24412/1609-2163-2022-3-63-66
  11. Achkasov EE, Bezuglov EN, Ul’yanov EN, et al. Application platelet-rich plasma in clinical practice. Biomedicine. 2013;(4):46–59. (In Russ).
  12. Volpi P, Zini R, Erschbaumer F, Beggio M, Busilacchi A, Carimati G. Effectiveness of a novel hydrolyzed collagen formulation in treating patients with symptomatic knee osteoarthritis: a multicentric retrospective clinical study. Int Orthop. 2021;45(2):375–380. doi: 10.1007/s00264-020-04616-8
  13. Kurshev VV, Litvinenko AS, Bezuglov EN, et al. Rehabilitation of athletes with diseases and injuries of the musculoskeletal system. Surgical practice. 2015;(3):71–77. (In Russ).
  14. Kumar S, Sugihara F, Suzuki K, et al. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. J Sci Food Agric. 2015;95(4):702–707. doi: 10.1002/jsfa.6752
  15. Mobasheri A, Mahmoudian A, Kalvaityte U, Uzieliene I, Larder CE, et al. A white paper on collagen hydrolyzates and ultrahydrolyzates: potential supplements to support joint health in Osteoarthritis? Curr Rheumatol Rep. 2021;23(11):78. doi: 10.1007/s11926-021-01042-6
  16. León-López A, Morales-Peñaloza A, Martínez-Juárez VM, et al. Hydrolyzed collagen-sources and applications. Molecules. 2019;24(22):4031. doi: 10.3390/molecules24224031
  17. Skov K, Oxfeldt M, Thøgersen R, et al. Enzymatic hydrolysis of a collagen hydrolysate enhances postprandial absorption rate. Nutrients. 2019;11(5):1064. doi: 10.3390/nu11051064
  18. Trc T, Bohmova J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. Glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). International Int Orthop. 2011;35(3):341–348. doi: 10.1007/s00264-010-1010-z
  19. Moskowitz RW. Role of Collagen hydrolysate in Bone and Joint disease. Semin Arthritis Rheum. 2000;30(2):87–99. doi: 10.1053/sarh.2000.9622
  20. Watanabe-Kamiyama M, Shimizu M, Kamiyama S, Taguchi Y, Sone H, et al. Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rat. J Agric Food Chem. 2010;58(2):835–841. doi: 10.1021/jf9031487
  21. Sugihara F, Inoue N, Kuwamori M, Taniguchi M. Quantification of hydroxyprolyl-glycine (Hyp-Gly) in human blood after ingestion of collagen hydrolysate. J Biosci Bioeng. 2012;113(2):202–203. doi: 10.1016/j.jbiosc.2011.09.02
  22. Oesser S, Seifert J. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res. 2003;311(3):393–399. doi: 10.1007/s00441-003-0702-8
  23. Oesser S, Adam M, Babel W, Seifert J. Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL). J Nutr. 1999;129(10):1891–1895. doi: 10.1093/jn/129.10.1891
  24. Nakatani S, Mano H, Sampei C, Shimizu J, Wada M. Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo. Osteoarthr Cartil. 2009;17(12):1620–1627. doi: 10.1016/j.joca.2009.07.001

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2. Fig. 1. Mechanism of immunometabolic and phenotypic reprogramming of macrophages with peptides derived from hydrolyzed collagen.

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3. Fig. 2. Dynamics of regression of pain indicators by Visual Analogue Scale in groups. Note. * — reliability of differences between indicators (p <0.05) in the end of 3th month, ** — reliability of differences between indicators (р <0.05) in the end of 6th month.

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