Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones
- 作者: Filippova P.1, Chernov N.1, Shutov R.1, Yakovlev I.1
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隶属关系:
- St. Petersburg State Chemical Pharmaceutical University
- 期: 卷 89, 编号 12 (2019)
- 页面: 2471-2479
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223217
- DOI: https://doi.org/10.1134/S1070363219120235
- ID: 223217
如何引用文章
详细
A procedure has been developed and optimized for the synthesis of 3-{[4-methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones (as dihydrochlorides) by an unusual version of the Morita–Baylis–Hillman reaction. A number of the title compounds with various substituents in the chromene fragment and their deamination products have been synthesized, and their inhibitory activity against butyrylcholinesterase has been studied.
作者简介
P. Filippova
St. Petersburg State Chemical Pharmaceutical University
Email: nikita.chernov@pharminnotech.com
俄罗斯联邦, St. Petersburg, 197376
N. Chernov
St. Petersburg State Chemical Pharmaceutical University
编辑信件的主要联系方式.
Email: nikita.chernov@pharminnotech.com
俄罗斯联邦, St. Petersburg, 197376
R. Shutov
St. Petersburg State Chemical Pharmaceutical University
Email: nikita.chernov@pharminnotech.com
俄罗斯联邦, St. Petersburg, 197376
I. Yakovlev
St. Petersburg State Chemical Pharmaceutical University
Email: nikita.chernov@pharminnotech.com
俄罗斯联邦, St. Petersburg, 197376