Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones
- Authors: Filippova P.V.1, Chernov N.M.1, Shutov R.V.1, Yakovlev I.P.1
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Affiliations:
- St. Petersburg State Chemical Pharmaceutical University
- Issue: Vol 89, No 12 (2019)
- Pages: 2471-2479
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223217
- DOI: https://doi.org/10.1134/S1070363219120235
- ID: 223217
Cite item
Abstract
A procedure has been developed and optimized for the synthesis of 3-{[4-methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones (as dihydrochlorides) by an unusual version of the Morita–Baylis–Hillman reaction. A number of the title compounds with various substituents in the chromene fragment and their deamination products have been synthesized, and their inhibitory activity against butyrylcholinesterase has been studied.
About the authors
P. V. Filippova
St. Petersburg State Chemical Pharmaceutical University
Email: nikita.chernov@pharminnotech.com
Russian Federation, St. Petersburg, 197376
N. M. Chernov
St. Petersburg State Chemical Pharmaceutical University
Author for correspondence.
Email: nikita.chernov@pharminnotech.com
Russian Federation, St. Petersburg, 197376
R. V. Shutov
St. Petersburg State Chemical Pharmaceutical University
Email: nikita.chernov@pharminnotech.com
Russian Federation, St. Petersburg, 197376
I. P. Yakovlev
St. Petersburg State Chemical Pharmaceutical University
Email: nikita.chernov@pharminnotech.com
Russian Federation, St. Petersburg, 197376