Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones
- Авторы: Filippova P.1, Chernov N.1, Shutov R.1, Yakovlev I.1
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Учреждения:
- St. Petersburg State Chemical Pharmaceutical University
- Выпуск: Том 89, № 12 (2019)
- Страницы: 2471-2479
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223217
- DOI: https://doi.org/10.1134/S1070363219120235
- ID: 223217
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Аннотация
A procedure has been developed and optimized for the synthesis of 3-{[4-methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones (as dihydrochlorides) by an unusual version of the Morita–Baylis–Hillman reaction. A number of the title compounds with various substituents in the chromene fragment and their deamination products have been synthesized, and their inhibitory activity against butyrylcholinesterase has been studied.
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Об авторах
P. Filippova
St. Petersburg State Chemical Pharmaceutical University
Email: nikita.chernov@pharminnotech.com
Россия, St. Petersburg, 197376
N. Chernov
St. Petersburg State Chemical Pharmaceutical University
Автор, ответственный за переписку.
Email: nikita.chernov@pharminnotech.com
Россия, St. Petersburg, 197376
R. Shutov
St. Petersburg State Chemical Pharmaceutical University
Email: nikita.chernov@pharminnotech.com
Россия, St. Petersburg, 197376
I. Yakovlev
St. Petersburg State Chemical Pharmaceutical University
Email: nikita.chernov@pharminnotech.com
Россия, St. Petersburg, 197376