Reactions of Ethyl 5-Methyl-4-(1,2,3-thiadiazol-4-yl)furan-2-carboxylate with Selected Bases
- 作者: Remizov Y.1, Pevzner L.1, Petrov M.1
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隶属关系:
- St. Petersburg State Institute of Technology
- 期: 卷 89, 编号 10 (2019)
- 页面: 2147-2150
- 栏目: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/223136
- DOI: https://doi.org/10.1134/S1070363219100256
- ID: 223136
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详细
The reactions of 5-methyl-4-(1,2,3-thiadiazol-4-yl)furan-2-carboxylic acid ethyl ester with some bases have been studied. The opening of 1,2,3-thiadiazole ring under the action of potassium tert-butylate in tetrahydrofuran in the presence of methyl iodide has led to the corresponding 4-methylsulfanylethynylfuran derivative. Under the action of potassium carbonate in DMF with an excess of primary amines or morpholine, the starting thiadiazole has formed the corresponding thioamides of furylacetic acid. The reaction of ethyl 5-methyl-4-(1,2,3-thiadiazol-4-yl)furan-2-carboxylate with hydrazine hydrate has led to hydrazinolysis of the ester group without cleavage of the 1,2,3-thiadiazole ring.
作者简介
Yu. Remizov
St. Petersburg State Institute of Technology
Email: pevzner_lm@list.ru
俄罗斯联邦, Moskovskii pr. 26, St. Petersburg, 190013
L. Pevzner
St. Petersburg State Institute of Technology
编辑信件的主要联系方式.
Email: pevzner_lm@list.ru
俄罗斯联邦, Moskovskii pr. 26, St. Petersburg, 190013
M. Petrov
St. Petersburg State Institute of Technology
Email: pevzner_lm@list.ru
俄罗斯联邦, Moskovskii pr. 26, St. Petersburg, 190013