Reactions of Ethyl 5-Methyl-4-(1,2,3-thiadiazol-4-yl)furan-2-carboxylate with Selected Bases
- Authors: Remizov Y.O.1, Pevzner L.M.1, Petrov M.L.1
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Affiliations:
- St. Petersburg State Institute of Technology
- Issue: Vol 89, No 10 (2019)
- Pages: 2147-2150
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/223136
- DOI: https://doi.org/10.1134/S1070363219100256
- ID: 223136
Cite item
Abstract
The reactions of 5-methyl-4-(1,2,3-thiadiazol-4-yl)furan-2-carboxylic acid ethyl ester with some bases have been studied. The opening of 1,2,3-thiadiazole ring under the action of potassium tert-butylate in tetrahydrofuran in the presence of methyl iodide has led to the corresponding 4-methylsulfanylethynylfuran derivative. Under the action of potassium carbonate in DMF with an excess of primary amines or morpholine, the starting thiadiazole has formed the corresponding thioamides of furylacetic acid. The reaction of ethyl 5-methyl-4-(1,2,3-thiadiazol-4-yl)furan-2-carboxylate with hydrazine hydrate has led to hydrazinolysis of the ester group without cleavage of the 1,2,3-thiadiazole ring.
About the authors
Yu. O. Remizov
St. Petersburg State Institute of Technology
Email: pevzner_lm@list.ru
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190013
L. M. Pevzner
St. Petersburg State Institute of Technology
Author for correspondence.
Email: pevzner_lm@list.ru
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190013
M. L. Petrov
St. Petersburg State Institute of Technology
Email: pevzner_lm@list.ru
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190013