Microwave Assisted Synthesis of 5-[4-(3-Phenyl-4,5-dihydro-1H-pyrazol-5-yl)phenyl]-1H-tetrazole Derivatives and Their Antimicrobial Activity
- 作者: Ashok D.1, Nagaraju N.1, Lakshmi B.1, Sarasija M.2
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隶属关系:
- Green and Medicinal Chemistry Laboratory, Department of Chemistry
- Department of Chemistry
- 期: 卷 89, 编号 9 (2019)
- 页面: 1905-1910
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223093
- DOI: https://doi.org/10.1134/S1070363219090275
- ID: 223093
如何引用文章
详细
In the present study, we report the synthesis of 5-[4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)phenyl]-1H-tetrazole derivatives by the Michael addition of chalcones to hydrazine hydrate in presence of acetic acid under conventional heating and microwave irradiation. All the synthesized compounds are characterized by IR, NMR, and mass spectra. The products are screened for their in vitro antimicrobial activity against strains such as Staphylococcus aurous, Bacillus subtilis, Klebsiella pneumonia, Escherichia coli, Aspergillus Niger, Aspergillus flavus, and Fusarium oxysporum. Most of the compounds exhibit high activity.
作者简介
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry
编辑信件的主要联系方式.
Email: ashokdou@gmail.com
印度, Hyderabad, Telangana, 500007
N. Nagaraju
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
印度, Hyderabad, Telangana, 500007
B. Lakshmi
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
印度, Hyderabad, Telangana, 500007
M. Sarasija
Department of Chemistry
Email: ashokdou@gmail.com
印度, Karimnagar, Telangana, 505001
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