Microwave Assisted Synthesis of 5-[4-(3-Phenyl-4,5-dihydro-1H-pyrazol-5-yl)phenyl]-1H-tetrazole Derivatives and Their Antimicrobial Activity
- Authors: Ashok D.1, Nagaraju N.1, Lakshmi B.V.1, Sarasija M.2
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Affiliations:
- Green and Medicinal Chemistry Laboratory, Department of Chemistry
- Department of Chemistry
- Issue: Vol 89, No 9 (2019)
- Pages: 1905-1910
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223093
- DOI: https://doi.org/10.1134/S1070363219090275
- ID: 223093
Cite item
Abstract
In the present study, we report the synthesis of 5-[4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)phenyl]-1H-tetrazole derivatives by the Michael addition of chalcones to hydrazine hydrate in presence of acetic acid under conventional heating and microwave irradiation. All the synthesized compounds are characterized by IR, NMR, and mass spectra. The products are screened for their in vitro antimicrobial activity against strains such as Staphylococcus aurous, Bacillus subtilis, Klebsiella pneumonia, Escherichia coli, Aspergillus Niger, Aspergillus flavus, and Fusarium oxysporum. Most of the compounds exhibit high activity.
About the authors
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Author for correspondence.
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500007
N. Nagaraju
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500007
B. Vijaya Lakshmi
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500007
M. Sarasija
Department of Chemistry
Email: ashokdou@gmail.com
India, Karimnagar, Telangana, 505001
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