Microwave Assisted Synthesis of 5-[4-(3-Phenyl-4,5-dihydro-1H-pyrazol-5-yl)phenyl]-1H-tetrazole Derivatives and Their Antimicrobial Activity
- Авторлар: Ashok D.1, Nagaraju N.1, Lakshmi B.1, Sarasija M.2
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Мекемелер:
- Green and Medicinal Chemistry Laboratory, Department of Chemistry
- Department of Chemistry
- Шығарылым: Том 89, № 9 (2019)
- Беттер: 1905-1910
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223093
- DOI: https://doi.org/10.1134/S1070363219090275
- ID: 223093
Дәйексөз келтіру
Аннотация
In the present study, we report the synthesis of 5-[4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)phenyl]-1H-tetrazole derivatives by the Michael addition of chalcones to hydrazine hydrate in presence of acetic acid under conventional heating and microwave irradiation. All the synthesized compounds are characterized by IR, NMR, and mass spectra. The products are screened for their in vitro antimicrobial activity against strains such as Staphylococcus aurous, Bacillus subtilis, Klebsiella pneumonia, Escherichia coli, Aspergillus Niger, Aspergillus flavus, and Fusarium oxysporum. Most of the compounds exhibit high activity.
Авторлар туралы
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Хат алмасуға жауапты Автор.
Email: ashokdou@gmail.com
Үндістан, Hyderabad, Telangana, 500007
N. Nagaraju
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
Үндістан, Hyderabad, Telangana, 500007
B. Lakshmi
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
Үндістан, Hyderabad, Telangana, 500007
M. Sarasija
Department of Chemistry
Email: ashokdou@gmail.com
Үндістан, Karimnagar, Telangana, 505001