Synthesis and Anticancer Evaluation of 2-{4-[5-(5-Substituted arylpyrimidin-2-yl)-1H-pyrazol-3-yl]-phenyl}thiazolo[4,5-b]pyridine Derivatives
- 作者: Koteswara Rao C.1, Rao T.1, Charan G.1, Srinu B.1, Maturi S.1
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隶属关系:
- Department of Chemistry
- 期: 卷 89, 编号 5 (2019)
- 页面: 1023-1028
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222918
- DOI: https://doi.org/10.1134/S1070363219050244
- ID: 222918
如何引用文章
详细
In the present study a new series of 2-{4-[5-(5-substituted arylpyrimidin-2-yl)-1H-pyrazol-3-yl] phenyl}thiazolo[4,5-b]pyridine derivatives (11a–11j) are synthesized and tested for their anticancer activity against four human cancer cell lines including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian) by the MTT assay. Among synthesized compounds, 11b, 11c, 11d, 11g, and 11j exhibit activity higher than the standard drug.
作者简介
Ch. Koteswara Rao
Department of Chemistry
Email: tbhaskararao208@gmail.com
印度, Vaddeswaram, Guntur, 522502
T. Rao
Department of Chemistry
编辑信件的主要联系方式.
Email: tbhaskararao208@gmail.com
印度, Vaddeswaram, Guntur, 522502
G. Charan
Department of Chemistry
Email: tbhaskararao208@gmail.com
印度, Vaddeswaram, Guntur, 522502
B. Srinu
Department of Chemistry
Email: tbhaskararao208@gmail.com
印度, Vaddeswaram, Guntur, 522502
S. Maturi
Department of Chemistry
Email: tbhaskararao208@gmail.com
印度, Vaddeswaram, Guntur, 522502