Synthesis and Anticancer Evaluation of 2-{4-[5-(5-Substituted arylpyrimidin-2-yl)-1H-pyrazol-3-yl]-phenyl}thiazolo[4,5-b]pyridine Derivatives
- Authors: Koteswara Rao C.P.1, Rao T.B.1, Charan G.K.1, Srinu B.1, Maturi S.R.1
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Affiliations:
- Department of Chemistry
- Issue: Vol 89, No 5 (2019)
- Pages: 1023-1028
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222918
- DOI: https://doi.org/10.1134/S1070363219050244
- ID: 222918
Cite item
Abstract
In the present study a new series of 2-{4-[5-(5-substituted arylpyrimidin-2-yl)-1H-pyrazol-3-yl] phenyl}thiazolo[4,5-b]pyridine derivatives (11a–11j) are synthesized and tested for their anticancer activity against four human cancer cell lines including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian) by the MTT assay. Among synthesized compounds, 11b, 11c, 11d, 11g, and 11j exhibit activity higher than the standard drug.
Keywords
About the authors
Ch. P. Koteswara Rao
Department of Chemistry
Email: tbhaskararao208@gmail.com
India, Vaddeswaram, Guntur, 522502
T. B. Rao
Department of Chemistry
Author for correspondence.
Email: tbhaskararao208@gmail.com
India, Vaddeswaram, Guntur, 522502
G. Kali Charan
Department of Chemistry
Email: tbhaskararao208@gmail.com
India, Vaddeswaram, Guntur, 522502
B. Srinu
Department of Chemistry
Email: tbhaskararao208@gmail.com
India, Vaddeswaram, Guntur, 522502
S. R. Maturi
Department of Chemistry
Email: tbhaskararao208@gmail.com
India, Vaddeswaram, Guntur, 522502