Synthesis and Anticancer Evaluation of 2-{4-[5-(5-Substituted arylpyrimidin-2-yl)-1H-pyrazol-3-yl]-phenyl}thiazolo[4,5-b]pyridine Derivatives
- Autores: Koteswara Rao C.1, Rao T.1, Charan G.1, Srinu B.1, Maturi S.1
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Afiliações:
- Department of Chemistry
- Edição: Volume 89, Nº 5 (2019)
- Páginas: 1023-1028
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222918
- DOI: https://doi.org/10.1134/S1070363219050244
- ID: 222918
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Resumo
In the present study a new series of 2-{4-[5-(5-substituted arylpyrimidin-2-yl)-1H-pyrazol-3-yl] phenyl}thiazolo[4,5-b]pyridine derivatives (11a–11j) are synthesized and tested for their anticancer activity against four human cancer cell lines including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian) by the MTT assay. Among synthesized compounds, 11b, 11c, 11d, 11g, and 11j exhibit activity higher than the standard drug.
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Sobre autores
Ch. Koteswara Rao
Department of Chemistry
Email: tbhaskararao208@gmail.com
Índia, Vaddeswaram, Guntur, 522502
T. Rao
Department of Chemistry
Autor responsável pela correspondência
Email: tbhaskararao208@gmail.com
Índia, Vaddeswaram, Guntur, 522502
G. Charan
Department of Chemistry
Email: tbhaskararao208@gmail.com
Índia, Vaddeswaram, Guntur, 522502
B. Srinu
Department of Chemistry
Email: tbhaskararao208@gmail.com
Índia, Vaddeswaram, Guntur, 522502
S. Maturi
Department of Chemistry
Email: tbhaskararao208@gmail.com
Índia, Vaddeswaram, Guntur, 522502