An Efficient Oxidative Difunctionalisation of 2-Amino-2H-chromene and Antimicrobial Activity of the Synthesized Tetrahydrochromene Derivatives
- 作者: Nagamani M.1, Jalapathi P.1, Shankar B.1, Neelamma M.1, Krishna T.2
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隶属关系:
- Department of Chemistry
- Department of Biotechnology
- 期: 卷 89, 编号 5 (2019)
- 页面: 998-1002
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222913
- DOI: https://doi.org/10.1134/S1070363219050207
- ID: 222913
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详细
A novel series of 3-amino-2,2-dialcoxy-7,7-dimethyl-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-3-carbonitriles are synthesized by oxidative difunctionalization (geminal dialkoxylation and migration of the amino group) of 2-amino-4-aryl-7,7-dimethyyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles in the presence of iodobenzenediacetate in water medium with excellent yields. All the newly synthesized compounds are characterized by IR, 1H and 13C NMR and Mass spectral data. The representative synthesized analogues are screened in vitro for antibacterial and antifungal activity using Gentamycin sulphate and Nystatin as standard drugs.
作者简介
M. Nagamani
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
印度, Hyderabad, Telangana
P. Jalapathi
Department of Chemistry
编辑信件的主要联系方式.
Email: pochampalli.ou.chemi@gmail.com
印度, Hyderabad, Telangana
B. Shankar
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
印度, Hyderabad, Telangana
M. Neelamma
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
印度, Hyderabad, Telangana
T. Krishna
Department of Biotechnology
Email: pochampalli.ou.chemi@gmail.com
印度, Warangal, Telangana