An Efficient Oxidative Difunctionalisation of 2-Amino-2H-chromene and Antimicrobial Activity of the Synthesized Tetrahydrochromene Derivatives
- Authors: Nagamani M.1, Jalapathi P.1, Shankar B.1, Neelamma M.1, Krishna T.M.2
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Affiliations:
- Department of Chemistry
- Department of Biotechnology
- Issue: Vol 89, No 5 (2019)
- Pages: 998-1002
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222913
- DOI: https://doi.org/10.1134/S1070363219050207
- ID: 222913
Cite item
Abstract
A novel series of 3-amino-2,2-dialcoxy-7,7-dimethyl-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-3-carbonitriles are synthesized by oxidative difunctionalization (geminal dialkoxylation and migration of the amino group) of 2-amino-4-aryl-7,7-dimethyyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles in the presence of iodobenzenediacetate in water medium with excellent yields. All the newly synthesized compounds are characterized by IR, 1H and 13C NMR and Mass spectral data. The representative synthesized analogues are screened in vitro for antibacterial and antifungal activity using Gentamycin sulphate and Nystatin as standard drugs.
About the authors
M. Nagamani
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
India, Hyderabad, Telangana
P. Jalapathi
Department of Chemistry
Author for correspondence.
Email: pochampalli.ou.chemi@gmail.com
India, Hyderabad, Telangana
B. Shankar
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
India, Hyderabad, Telangana
M. Neelamma
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
India, Hyderabad, Telangana
T. M. Krishna
Department of Biotechnology
Email: pochampalli.ou.chemi@gmail.com
India, Warangal, Telangana