An Efficient Oxidative Difunctionalisation of 2-Amino-2H-chromene and Antimicrobial Activity of the Synthesized Tetrahydrochromene Derivatives
- Autores: Nagamani M.1, Jalapathi P.1, Shankar B.1, Neelamma M.1, Krishna T.2
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Afiliações:
- Department of Chemistry
- Department of Biotechnology
- Edição: Volume 89, Nº 5 (2019)
- Páginas: 998-1002
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222913
- DOI: https://doi.org/10.1134/S1070363219050207
- ID: 222913
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Resumo
A novel series of 3-amino-2,2-dialcoxy-7,7-dimethyl-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-3-carbonitriles are synthesized by oxidative difunctionalization (geminal dialkoxylation and migration of the amino group) of 2-amino-4-aryl-7,7-dimethyyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles in the presence of iodobenzenediacetate in water medium with excellent yields. All the newly synthesized compounds are characterized by IR, 1H and 13C NMR and Mass spectral data. The representative synthesized analogues are screened in vitro for antibacterial and antifungal activity using Gentamycin sulphate and Nystatin as standard drugs.
Sobre autores
M. Nagamani
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
Índia, Hyderabad, Telangana
P. Jalapathi
Department of Chemistry
Autor responsável pela correspondência
Email: pochampalli.ou.chemi@gmail.com
Índia, Hyderabad, Telangana
B. Shankar
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
Índia, Hyderabad, Telangana
M. Neelamma
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
Índia, Hyderabad, Telangana
T. Krishna
Department of Biotechnology
Email: pochampalli.ou.chemi@gmail.com
Índia, Warangal, Telangana