2-Cyano-3-(dimethylamino)prop-2-ene Thioamide: A New Reagent for Synthesis of Functionalized 4-Unsubstituted Ethyl Nicotinates and Nicotinonitriles

详细

Condensation of cyclopent(hex)ylidenecyanothioacetamide with N, N-dimethylformamide dimethyl acetal led to the formation of a new reagent for organic synthesis: 2-cyano-3-(dimethylamino)prop-2-ene thioamide. On its basis a series of ethyl nicotinates and nicotinonitriles were synthesized by a vinyl substitution reaction.