Synthesis, Antitubercular Activity, and Molecular Docking Studies of Novel 2-(4-Chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamides
- 作者: Srinu B.1, Parameshwar R.2, Kali Charan G.1, Srinivas E.1, Koteswara Rao C.1, Narendra Sharath Chandra J.2, Naresh Varma S.1
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隶属关系:
- Department of Chemistry
- Department of Pharmaceutical Chemistry
- 期: 卷 89, 编号 4 (2019)
- 页面: 836-843
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222884
- DOI: https://doi.org/10.1134/S1070363219040327
- ID: 222884
如何引用文章
详细
A novel series of 2-(4-chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamide derivatives are synthesized and their structures are confirmed by 1H and 13C NMR, and MS spectral data. The compounds are screened for their antitubercular activity, and those with aryl moiety 7o, 7q, and 7r demonstrate potent activity against Mycobacterium tuberculosis. Docking studies suggest a mode of interaction of the products with the binding site of enoyl-CoA hydratase demonstrating that the target compounds were potential anti-TB agents.
作者简介
B. Srinu
Department of Chemistry
Email: nareshvarma.klu@gmail.com
印度, Vaddeswaram, Guntur, 522502
R. Parameshwar
Department of Pharmaceutical Chemistry
Email: nareshvarma.klu@gmail.com
印度, Hyderabad, 501506
G. Kali Charan
Department of Chemistry
Email: nareshvarma.klu@gmail.com
印度, Vaddeswaram, Guntur, 522502
E. Srinivas
Department of Chemistry
Email: nareshvarma.klu@gmail.com
印度, Vaddeswaram, Guntur, 522502
Ch. Koteswara Rao
Department of Chemistry
Email: nareshvarma.klu@gmail.com
印度, Vaddeswaram, Guntur, 522502
J. Narendra Sharath Chandra
Department of Pharmaceutical Chemistry
Email: nareshvarma.klu@gmail.com
印度, Maharashtra, 431129
S. Naresh Varma
Department of Chemistry
编辑信件的主要联系方式.
Email: nareshvarma.klu@gmail.com
印度, Vaddeswaram, Guntur, 522502
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