Synthesis, Antitubercular Activity, and Molecular Docking Studies of Novel 2-(4-Chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamides
- Авторлар: Srinu B.1, Parameshwar R.2, Kali Charan G.1, Srinivas E.1, Koteswara Rao C.1, Narendra Sharath Chandra J.2, Naresh Varma S.1
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Мекемелер:
- Department of Chemistry
- Department of Pharmaceutical Chemistry
- Шығарылым: Том 89, № 4 (2019)
- Беттер: 836-843
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222884
- DOI: https://doi.org/10.1134/S1070363219040327
- ID: 222884
Дәйексөз келтіру
Аннотация
A novel series of 2-(4-chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamide derivatives are synthesized and their structures are confirmed by 1H and 13C NMR, and MS spectral data. The compounds are screened for their antitubercular activity, and those with aryl moiety 7o, 7q, and 7r demonstrate potent activity against Mycobacterium tuberculosis. Docking studies suggest a mode of interaction of the products with the binding site of enoyl-CoA hydratase demonstrating that the target compounds were potential anti-TB agents.
Негізгі сөздер
Авторлар туралы
B. Srinu
Department of Chemistry
Email: nareshvarma.klu@gmail.com
Үндістан, Vaddeswaram, Guntur, 522502
R. Parameshwar
Department of Pharmaceutical Chemistry
Email: nareshvarma.klu@gmail.com
Үндістан, Hyderabad, 501506
G. Kali Charan
Department of Chemistry
Email: nareshvarma.klu@gmail.com
Үндістан, Vaddeswaram, Guntur, 522502
E. Srinivas
Department of Chemistry
Email: nareshvarma.klu@gmail.com
Үндістан, Vaddeswaram, Guntur, 522502
Ch. Koteswara Rao
Department of Chemistry
Email: nareshvarma.klu@gmail.com
Үндістан, Vaddeswaram, Guntur, 522502
J. Narendra Sharath Chandra
Department of Pharmaceutical Chemistry
Email: nareshvarma.klu@gmail.com
Үндістан, Maharashtra, 431129
S. Naresh Varma
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: nareshvarma.klu@gmail.com
Үндістан, Vaddeswaram, Guntur, 522502
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