Synthesis, Antitubercular Activity, and Molecular Docking Studies of Novel 2-(4-Chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamides
- Авторы: Srinu B.1, Parameshwar R.2, Kali Charan G.1, Srinivas E.1, Koteswara Rao C.1, Narendra Sharath Chandra J.2, Naresh Varma S.1
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Учреждения:
- Department of Chemistry
- Department of Pharmaceutical Chemistry
- Выпуск: Том 89, № 4 (2019)
- Страницы: 836-843
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222884
- DOI: https://doi.org/10.1134/S1070363219040327
- ID: 222884
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Аннотация
A novel series of 2-(4-chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamide derivatives are synthesized and their structures are confirmed by 1H and 13C NMR, and MS spectral data. The compounds are screened for their antitubercular activity, and those with aryl moiety 7o, 7q, and 7r demonstrate potent activity against Mycobacterium tuberculosis. Docking studies suggest a mode of interaction of the products with the binding site of enoyl-CoA hydratase demonstrating that the target compounds were potential anti-TB agents.
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Об авторах
B. Srinu
Department of Chemistry
Email: nareshvarma.klu@gmail.com
Индия, Vaddeswaram, Guntur, 522502
R. Parameshwar
Department of Pharmaceutical Chemistry
Email: nareshvarma.klu@gmail.com
Индия, Hyderabad, 501506
G. Kali Charan
Department of Chemistry
Email: nareshvarma.klu@gmail.com
Индия, Vaddeswaram, Guntur, 522502
E. Srinivas
Department of Chemistry
Email: nareshvarma.klu@gmail.com
Индия, Vaddeswaram, Guntur, 522502
Ch. Koteswara Rao
Department of Chemistry
Email: nareshvarma.klu@gmail.com
Индия, Vaddeswaram, Guntur, 522502
J. Narendra Sharath Chandra
Department of Pharmaceutical Chemistry
Email: nareshvarma.klu@gmail.com
Индия, Maharashtra, 431129
S. Naresh Varma
Department of Chemistry
Автор, ответственный за переписку.
Email: nareshvarma.klu@gmail.com
Индия, Vaddeswaram, Guntur, 522502