Synthesis and Antifungal Activity of (±)-4-Methoxy Decanoic Acid and Its Novel Amide Derivatives

详细

A simple synthetic route has been developed for fatty acid, (±)-4-methoxy decanoic acid (1), in 4 steps with 42% overall yield. The novel amide derivatives of 1 are synthesized. The in vitro antifungal activity of 1 and its novel amide derivatives 1a–1f has been evaluated against different organisms. Compounds 1e, 1f exhibited antifungal activity higher than the parent compound 1 against macrophomina phaseolina, and 1a, 1d exhibited antifungal activity against sclerotium rolfsii.