Email this article Synthesis and Antifungal Activity of (±)-4-Methoxy Decanoic Acid and Its Novel Amide Derivatives
- Authors: Subhashini N.J.1, Ashok Kumar P.1, Bhaskar Reddy C.1, Lingaiah B.1, Bee H.2
-
Affiliations:
- Department of Chemistry, University College of Science
- Department of Microbiology, University College of Science
- Issue: Vol 88, No 3 (2018)
- Pages: 532-536
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222075
- DOI: https://doi.org/10.1134/S1070363218030222
- ID: 222075
Cite item
Open Access
Access granted
Subscription Access
Abstract
A simple synthetic route has been developed for fatty acid, (±)-4-methoxy decanoic acid (1), in 4 steps with 42% overall yield. The novel amide derivatives of 1 are synthesized. The in vitro antifungal activity of 1 and its novel amide derivatives 1a–1f has been evaluated against different organisms. Compounds 1e, 1f exhibited antifungal activity higher than the parent compound 1 against macrophomina phaseolina, and 1a, 1d exhibited antifungal activity against sclerotium rolfsii.
About the authors
N. J. P. Subhashini
Department of Chemistry, University College of Science
Author for correspondence.
Email: njsubhashini@yahoo.co.in
India, Hyderabad, 500007
P. Ashok Kumar
Department of Chemistry, University College of Science
Email: njsubhashini@yahoo.co.in
India, Hyderabad, 500007
Ch. Bhaskar Reddy
Department of Chemistry, University College of Science
Email: njsubhashini@yahoo.co.in
India, Hyderabad, 500007
B. Lingaiah
Department of Chemistry, University College of Science
Email: njsubhashini@yahoo.co.in
India, Hyderabad, 500007
Hameeda Bee
Department of Microbiology, University College of Science
Email: njsubhashini@yahoo.co.in
India, Hyderabad, 500007
