Design, Synthesis, and Cytotoxicity of Semisynthetic Betulinic Acid-1,2,4-Oxadiazole Amide Derivatives
- 作者: Krishna C.1, Bhargavi M.2, Krupadanam G.1
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隶属关系:
- Department of Chemistry, Faculty of Science
- Department of Pharmacy, Faculty of Technology
- 期: 卷 88, 编号 2 (2018)
- 页面: 312-318
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222013
- DOI: https://doi.org/10.1134/S1070363218020196
- ID: 222013
如何引用文章
详细
Biological activity of betulinic acid derivatives containing a 1,2,4-oxadiazole ring prompted us to synthesize betulinic acid-1,2,4-oxadiazole amide derivatives 14–25 starting with the amide coupling reaction of betulinic acid 1 and (3-aryl-1,2,4-oxadiazol-5-yl)methanamines 2–13. The products were tested for cytotoxicity on three human cancer cell lines in vitro. All tested compounds demonstrated high activity. The structures of the synthesized compounds were elucidated from IR, NMR and mass spectra.
作者简介
C. Krishna
Department of Chemistry, Faculty of Science
编辑信件的主要联系方式.
Email: challakrishna76@gmail.com
印度, Hyderabad, 500007
M. Bhargavi
Department of Pharmacy, Faculty of Technology
Email: challakrishna76@gmail.com
印度, Hyderabad, 500007
G. Krupadanam
Department of Chemistry, Faculty of Science
Email: challakrishna76@gmail.com
印度, Hyderabad, 500007