Design, Synthesis, and Cytotoxicity of Semisynthetic Betulinic Acid-1,2,4-Oxadiazole Amide Derivatives
- Авторы: Krishna C.1, Bhargavi M.2, Krupadanam G.1
-
Учреждения:
- Department of Chemistry, Faculty of Science
- Department of Pharmacy, Faculty of Technology
- Выпуск: Том 88, № 2 (2018)
- Страницы: 312-318
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222013
- DOI: https://doi.org/10.1134/S1070363218020196
- ID: 222013
Цитировать
Аннотация
Biological activity of betulinic acid derivatives containing a 1,2,4-oxadiazole ring prompted us to synthesize betulinic acid-1,2,4-oxadiazole amide derivatives 14–25 starting with the amide coupling reaction of betulinic acid 1 and (3-aryl-1,2,4-oxadiazol-5-yl)methanamines 2–13. The products were tested for cytotoxicity on three human cancer cell lines in vitro. All tested compounds demonstrated high activity. The structures of the synthesized compounds were elucidated from IR, NMR and mass spectra.
Ключевые слова
Об авторах
C. Krishna
Department of Chemistry, Faculty of Science
Автор, ответственный за переписку.
Email: challakrishna76@gmail.com
Индия, Hyderabad, 500007
M. Bhargavi
Department of Pharmacy, Faculty of Technology
Email: challakrishna76@gmail.com
Индия, Hyderabad, 500007
G. Krupadanam
Department of Chemistry, Faculty of Science
Email: challakrishna76@gmail.com
Индия, Hyderabad, 500007