Design, Synthesis, and Cytotoxicity of Semisynthetic Betulinic Acid-1,2,4-Oxadiazole Amide Derivatives
- Авторлар: Krishna C.1, Bhargavi M.2, Krupadanam G.1
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Мекемелер:
- Department of Chemistry, Faculty of Science
- Department of Pharmacy, Faculty of Technology
- Шығарылым: Том 88, № 2 (2018)
- Беттер: 312-318
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222013
- DOI: https://doi.org/10.1134/S1070363218020196
- ID: 222013
Дәйексөз келтіру
Аннотация
Biological activity of betulinic acid derivatives containing a 1,2,4-oxadiazole ring prompted us to synthesize betulinic acid-1,2,4-oxadiazole amide derivatives 14–25 starting with the amide coupling reaction of betulinic acid 1 and (3-aryl-1,2,4-oxadiazol-5-yl)methanamines 2–13. The products were tested for cytotoxicity on three human cancer cell lines in vitro. All tested compounds demonstrated high activity. The structures of the synthesized compounds were elucidated from IR, NMR and mass spectra.
Негізгі сөздер
Авторлар туралы
C. Krishna
Department of Chemistry, Faculty of Science
Хат алмасуға жауапты Автор.
Email: challakrishna76@gmail.com
Үндістан, Hyderabad, 500007
M. Bhargavi
Department of Pharmacy, Faculty of Technology
Email: challakrishna76@gmail.com
Үндістан, Hyderabad, 500007
G. Krupadanam
Department of Chemistry, Faculty of Science
Email: challakrishna76@gmail.com
Үндістан, Hyderabad, 500007