Synthesis of New 1,3-Thiazolecarbaldehydes
- 作者: Sinenko V.1, Slivchuk S.1, Mityukhin O.1, Brovarets V.1
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隶属关系:
- Institute of Bioorganic Chemistry and Petrochemistry
- 期: 卷 87, 编号 12 (2017)
- 页面: 2766-2775
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221676
- DOI: https://doi.org/10.1134/S1070363217120039
- ID: 221676
如何引用文章
详细
H-Lithiation and Br-lithiation reactions of 1,3-thiazole were studied in order to obtain new thiazole derivatives. Four isomeric chloromethyl derivatives of 1,3-thiazole containing a protected aldehyde group like 2-(1,3-dioxolan-2-yl)-5-(chloromethyl)-1,3-thiazole, 5-(1,3-dioxolan-2-yl)-2-(chloromethyl)-1,3-thiazole, 4-(1,3-dioxolan-2-yl)-2-(chloromethyl)-1,3-thiazole, and 2-(1,3-dioxolan-2-yl)-4-(chloromethyl)-1,3-thiazole were synthesized. Their nucleophilic substitution reactions with dimethylamine and sodium methylthiolate were studied. New aldehydes of 1,3-thiazole series of low-molecular weight were obtained.
作者简介
V. Sinenko
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
乌克兰, ul. Murmanskaya 1, Kiev, 02094
S. Slivchuk
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
乌克兰, ul. Murmanskaya 1, Kiev, 02094
O. Mityukhin
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
乌克兰, ul. Murmanskaya 1, Kiev, 02094
V. Brovarets
Institute of Bioorganic Chemistry and Petrochemistry
编辑信件的主要联系方式.
Email: brovarets@bpci.kiev.ua
乌克兰, ul. Murmanskaya 1, Kiev, 02094
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