Synthesis of New 1,3-Thiazolecarbaldehydes
- Authors: Sinenko V.O.1, Slivchuk S.R.1, Mityukhin O.P.1, Brovarets V.S.1
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Affiliations:
- Institute of Bioorganic Chemistry and Petrochemistry
- Issue: Vol 87, No 12 (2017)
- Pages: 2766-2775
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221676
- DOI: https://doi.org/10.1134/S1070363217120039
- ID: 221676
Cite item
Abstract
H-Lithiation and Br-lithiation reactions of 1,3-thiazole were studied in order to obtain new thiazole derivatives. Four isomeric chloromethyl derivatives of 1,3-thiazole containing a protected aldehyde group like 2-(1,3-dioxolan-2-yl)-5-(chloromethyl)-1,3-thiazole, 5-(1,3-dioxolan-2-yl)-2-(chloromethyl)-1,3-thiazole, 4-(1,3-dioxolan-2-yl)-2-(chloromethyl)-1,3-thiazole, and 2-(1,3-dioxolan-2-yl)-4-(chloromethyl)-1,3-thiazole were synthesized. Their nucleophilic substitution reactions with dimethylamine and sodium methylthiolate were studied. New aldehydes of 1,3-thiazole series of low-molecular weight were obtained.
About the authors
V. O. Sinenko
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kiev, 02094
S. R. Slivchuk
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kiev, 02094
O. P. Mityukhin
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kiev, 02094
V. S. Brovarets
Institute of Bioorganic Chemistry and Petrochemistry
Author for correspondence.
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kiev, 02094