Synthesis, spectroscopic characterization, and biological screening of levofloxacin based organotin(IV) derivatives
- 作者: Munir A.1, Sirajuddin M.1, Zubair M.1, Haider A.1, Tirmizi S.1, Ali S.1, Khan H.1, Ullah K.1, Aziz I.1
-
隶属关系:
- Department of Chemistry
- 期: 卷 87, 编号 10 (2017)
- 页面: 2380-2390
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221443
- DOI: https://doi.org/10.1134/S1070363217100206
- ID: 221443
如何引用文章
详细
Four new organotin (IV) complexes with general formula R3SnL/R2SnL2, where R = CH3, n-C4H9, C6H5 and L = Levofloxacin, were synthesized and characterized by elemental analyses, FT-IR and NMR (1H and 13C) spectroscopy. Spectroscopic data suggested a six-coordinated geometry for diorganotin(IV) derivatives and a five-coordinated geometry for triorganotin(IV) derivatives. The value of Me–Sn–Me bond angle for di- and trimethyltin complexes using the Lockhart equation, were 150° and 116°, respectively, that corresponded to six and five-coordinate geometry, accordingly. The ligand and its complexes were screened for their antibacterial, antifungal, cytotoxic, and free radical scavenging (DPPH) antioxidant activities. The biological data indicated those as potentially bioactive in each field of the study. Accumulated data of DNA interaction with the synthesized complexes based on UV-Vis, cyclic voltammetry and viscometry suggested an intercalative mode of the interaction.
作者简介
A. Munir
Department of Chemistry; Department of Chemistry
Email: drsa54@mail.com
巴基斯坦, Lahore; Islamabad, 45320
M. Sirajuddin
Department of Chemistry
编辑信件的主要联系方式.
Email: m.siraj09@yahoo.com
巴基斯坦, KPK, 28100
M. Zubair
Department of Chemistry
Email: drsa54@mail.com
巴基斯坦, Islamabad, 45320
A. Haider
Department of Chemistry
Email: drsa54@mail.com
巴基斯坦, Islamabad, 45320
S. Tirmizi
Department of Chemistry
Email: drsa54@mail.com
巴基斯坦, Islamabad, 45320
S. Ali
Department of Chemistry
编辑信件的主要联系方式.
Email: drsa54@mail.com
巴基斯坦, Islamabad, 45320
H. Khan
Department of Chemistry; Department of Chemistry
Email: drsa54@mail.com
巴基斯坦, Islamabad, 45320; KPK, 28100
K. Ullah
Department of Chemistry
Email: drsa54@mail.com
巴基斯坦, Islamabad, 45320
I. Aziz
Department of Chemistry
Email: drsa54@mail.com
巴基斯坦, Islamabad, 45320
![](/img/style/loading.gif)