Synthesis, spectroscopic characterization, and biological screening of levofloxacin based organotin(IV) derivatives
- Authors: Munir A.1, Sirajuddin M.1, Zubair M.1, Haider A.1, Tirmizi S.A.1, Ali S.1, Khan H.1, Ullah K.1, Aziz I.1
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Affiliations:
- Department of Chemistry
- Issue: Vol 87, No 10 (2017)
- Pages: 2380-2390
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221443
- DOI: https://doi.org/10.1134/S1070363217100206
- ID: 221443
Cite item
Abstract
Four new organotin (IV) complexes with general formula R3SnL/R2SnL2, where R = CH3, n-C4H9, C6H5 and L = Levofloxacin, were synthesized and characterized by elemental analyses, FT-IR and NMR (1H and 13C) spectroscopy. Spectroscopic data suggested a six-coordinated geometry for diorganotin(IV) derivatives and a five-coordinated geometry for triorganotin(IV) derivatives. The value of Me–Sn–Me bond angle for di- and trimethyltin complexes using the Lockhart equation, were 150° and 116°, respectively, that corresponded to six and five-coordinate geometry, accordingly. The ligand and its complexes were screened for their antibacterial, antifungal, cytotoxic, and free radical scavenging (DPPH) antioxidant activities. The biological data indicated those as potentially bioactive in each field of the study. Accumulated data of DNA interaction with the synthesized complexes based on UV-Vis, cyclic voltammetry and viscometry suggested an intercalative mode of the interaction.
About the authors
A. Munir
Department of Chemistry; Department of Chemistry
Email: drsa54@mail.com
Pakistan, Lahore; Islamabad, 45320
M. Sirajuddin
Department of Chemistry
Author for correspondence.
Email: m.siraj09@yahoo.com
Pakistan, KPK, 28100
M. Zubair
Department of Chemistry
Email: drsa54@mail.com
Pakistan, Islamabad, 45320
A. Haider
Department of Chemistry
Email: drsa54@mail.com
Pakistan, Islamabad, 45320
S. A. Tirmizi
Department of Chemistry
Email: drsa54@mail.com
Pakistan, Islamabad, 45320
S. Ali
Department of Chemistry
Author for correspondence.
Email: drsa54@mail.com
Pakistan, Islamabad, 45320
H. Khan
Department of Chemistry; Department of Chemistry
Email: drsa54@mail.com
Pakistan, Islamabad, 45320; KPK, 28100
K. Ullah
Department of Chemistry
Email: drsa54@mail.com
Pakistan, Islamabad, 45320
I. Aziz
Department of Chemistry
Email: drsa54@mail.com
Pakistan, Islamabad, 45320