Synthesis, spectroscopic characterization, and biological screening of levofloxacin based organotin(IV) derivatives

Abstract

Four new organotin (IV) complexes with general formula R₃SnL/R₂SnL₂, where R = CH₃, n-C₄H₉, C₆H₅ and L = Levofloxacin, were synthesized and characterized by elemental analyses, FT-IR and NMR (¹H and ¹³C) spectroscopy. Spectroscopic data suggested a six-coordinated geometry for diorganotin(IV) derivatives and a five-coordinated geometry for triorganotin(IV) derivatives. The value of Me–Sn–Me bond angle for di- and trimethyltin complexes using the Lockhart equation, were 150° and 116°, respectively, that corresponded to six and five-coordinate geometry, accordingly. The ligand and its complexes were screened for their antibacterial, antifungal, cytotoxic, and free radical scavenging (DPPH) antioxidant activities. The biological data indicated those as potentially bioactive in each field of the study. Accumulated data of DNA interaction with the synthesized complexes based on UV-Vis, cyclic voltammetry and viscometry suggested an intercalative mode of the interaction.