Synthesis and antiproliferative activity of new 1,2,3-triazole/flavone hybrid heterocycles against human cancer cell lines
- 作者: Sowjanya T.1, Jayaprakash Rao Y.1, Murthy N.1
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隶属关系:
- Department of Chemistry
- 期: 卷 87, 编号 8 (2017)
- 页面: 1864-1871
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221165
- DOI: https://doi.org/10.1134/S1070363217080357
- ID: 221165
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详细
A series of new 1,2,3-triazole/flavone hybrid heterocycles were synthesized from 6-amino flavone via key intermediate N-propargyl flavone 6 by adopting the Sharpless Click reaction. Copper(I) catalyzed 1,3-dipolar cycloaddition reaction that gave products in high yields. All the synthesized compounds were screened for their in vitro antiproliferative activity against four human cancer cell lines, HeLa (cervical cancer cell line), MIA PaCa (pancreatic cancer cell line), MDA-MB-231 (breast cancer cell line), and IMR 32 (neuroblastoma cancer cell line). Compounds 7a, 7b, 7d, 7g (GI50 = 0.01–0.68 μM) demonstrated promising antiproliferative activity.
作者简介
T. Sowjanya
Department of Chemistry
Email: yjpr_19@yahoo.com
印度, Hyderabad, 500072
Y. Jayaprakash Rao
Department of Chemistry; Department of Chemistry
编辑信件的主要联系方式.
Email: yjpr_19@yahoo.com
印度, Hyderabad, 500004; Nizamabad, 503322
N. Murthy
Department of Chemistry
Email: yjpr_19@yahoo.com
印度, Hyderabad, 500088