Synthesis and antiproliferative activity of new 1,2,3-triazole/flavone hybrid heterocycles against human cancer cell lines
- Autores: Sowjanya T.1, Jayaprakash Rao Y.1, Murthy N.1
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Afiliações:
- Department of Chemistry
- Edição: Volume 87, Nº 8 (2017)
- Páginas: 1864-1871
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221165
- DOI: https://doi.org/10.1134/S1070363217080357
- ID: 221165
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Resumo
A series of new 1,2,3-triazole/flavone hybrid heterocycles were synthesized from 6-amino flavone via key intermediate N-propargyl flavone 6 by adopting the Sharpless Click reaction. Copper(I) catalyzed 1,3-dipolar cycloaddition reaction that gave products in high yields. All the synthesized compounds were screened for their in vitro antiproliferative activity against four human cancer cell lines, HeLa (cervical cancer cell line), MIA PaCa (pancreatic cancer cell line), MDA-MB-231 (breast cancer cell line), and IMR 32 (neuroblastoma cancer cell line). Compounds 7a, 7b, 7d, 7g (GI50 = 0.01–0.68 μM) demonstrated promising antiproliferative activity.
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Sobre autores
T. Sowjanya
Department of Chemistry
Email: yjpr_19@yahoo.com
Índia, Hyderabad, 500072
Y. Jayaprakash Rao
Department of Chemistry; Department of Chemistry
Autor responsável pela correspondência
Email: yjpr_19@yahoo.com
Índia, Hyderabad, 500004; Nizamabad, 503322
N. Murthy
Department of Chemistry
Email: yjpr_19@yahoo.com
Índia, Hyderabad, 500088