Synthesis and antiproliferative activity of new 1,2,3-triazole/flavone hybrid heterocycles against human cancer cell lines
- Авторы: Sowjanya T.1, Jayaprakash Rao Y.1, Murthy N.1
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Учреждения:
- Department of Chemistry
- Выпуск: Том 87, № 8 (2017)
- Страницы: 1864-1871
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221165
- DOI: https://doi.org/10.1134/S1070363217080357
- ID: 221165
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Аннотация
A series of new 1,2,3-triazole/flavone hybrid heterocycles were synthesized from 6-amino flavone via key intermediate N-propargyl flavone 6 by adopting the Sharpless Click reaction. Copper(I) catalyzed 1,3-dipolar cycloaddition reaction that gave products in high yields. All the synthesized compounds were screened for their in vitro antiproliferative activity against four human cancer cell lines, HeLa (cervical cancer cell line), MIA PaCa (pancreatic cancer cell line), MDA-MB-231 (breast cancer cell line), and IMR 32 (neuroblastoma cancer cell line). Compounds 7a, 7b, 7d, 7g (GI50 = 0.01–0.68 μM) demonstrated promising antiproliferative activity.
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Об авторах
T. Sowjanya
Department of Chemistry
Email: yjpr_19@yahoo.com
Индия, Hyderabad, 500072
Y. Jayaprakash Rao
Department of Chemistry; Department of Chemistry
Автор, ответственный за переписку.
Email: yjpr_19@yahoo.com
Индия, Hyderabad, 500004; Nizamabad, 503322
N. Murthy
Department of Chemistry
Email: yjpr_19@yahoo.com
Индия, Hyderabad, 500088