A novel and efficient synthesis of 3-iodo substituted 1,8-naphthyridines by electrophilic cyclization of 2-amino nicotinaldehyde and their antimicrobial activity
- 作者: Sakram B.1, Ashok K.1, Rambabu S.1, Sonyanaik B.1, Ravi D.1
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隶属关系:
- Department of Chemistry
- 期: 卷 87, 编号 8 (2017)
- 页面: 1794-1799
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221072
- DOI: https://doi.org/10.1134/S1070363217080266
- ID: 221072
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详细
Synthesis of substituted 1,8-naphthyridines based on 2-aminonicotinaldehyde under mild conditions is studied. Out of three electrophilic iodine sources (I2, NIS, and ICl) studied, I2 was determined to act most efficiently in the process. High overall yields were achieved for aliphatic substitution at the reaction center. All compounds were evaluated for antibacterial activity (Staphylococus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia) and anti-fungi activity (Aspergillus flavus and Fusarium oxysporum).
作者简介
B. Sakram
Department of Chemistry
编辑信件的主要联系方式.
Email: bschemou@gmail.com
印度, Hyderabad, 500007
K. Ashok
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007