A novel and efficient synthesis of 3-iodo substituted 1,8-naphthyridines by electrophilic cyclization of 2-amino nicotinaldehyde and their antimicrobial activity
- Authors: Sakram B.1, Ashok K.1, Rambabu S.1, Sonyanaik B.1, Ravi D.1
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Affiliations:
- Department of Chemistry
- Issue: Vol 87, No 8 (2017)
- Pages: 1794-1799
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221072
- DOI: https://doi.org/10.1134/S1070363217080266
- ID: 221072
Cite item
Abstract
Synthesis of substituted 1,8-naphthyridines based on 2-aminonicotinaldehyde under mild conditions is studied. Out of three electrophilic iodine sources (I2, NIS, and ICl) studied, I2 was determined to act most efficiently in the process. High overall yields were achieved for aliphatic substitution at the reaction center. All compounds were evaluated for antibacterial activity (Staphylococus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia) and anti-fungi activity (Aspergillus flavus and Fusarium oxysporum).
About the authors
B. Sakram
Department of Chemistry
Author for correspondence.
Email: bschemou@gmail.com
India, Hyderabad, 500007
K. Ashok
Department of Chemistry
Email: bschemou@gmail.com
India, Hyderabad, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
India, Hyderabad, 500007
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
India, Hyderabad, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
India, Hyderabad, 500007