Synthesis of 3-oxoesters and functional derivatives of pyrimidin-4(3 Н )-one based on 1-(2,6-dihalophenyl)cyclopropan-1-carboxylic acids

I. A. Novakov; A. S. Yablokov; M. B. Navrotskii; A. S. Mkrtchyan; A. A. Vernigora; A. S. Babushkin; V. V. Kachala; E. A. Ruchko

doi:10.1134/S1070363217020128

Synthesis of 3-oxoesters and functional derivatives of pyrimidin-4(3Н)-one based on 1-(2,6-dihalophenyl)cyclopropan-1-carboxylic acids

作者: Novakov I.¹, Yablokov A.¹, Navrotskii M.¹, Mkrtchyan A.¹, Vernigora A.¹, Babushkin A.¹, Kachala V.², Ruchko E.³
隶属关系:
1. Volgograd State Technical University
2. Zelinskii Institute of Organic Chemistry
3. Farmsintez
期: 卷 87, 编号 2 (2017)
页面: 224-230
栏目: Article
URL: https://journals.rcsi.science/1070-3632/article/view/218190
DOI: https://doi.org/10.1134/S1070363217020128
ID: 218190

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Special features of the synthesis and chemical transformations of novel functional derivatives of 6-[1-(2,6-dihalophenyl)cyclopropyl]pyrimidin-4(3H)-one and ethyl esters of 3-[1-(2,6-dihalophenyl)cyclopropyl]-2-methyl-3-oxopropanoic acids prepared from 2-(2,6-dihalophenyl)acetonitriles have been revealed. Novel achiral structural analogs of experimental anti-HIV agent МС-1501 have been synthesized.