Organotin(IV) O-butyl carbonodithioates: Synthesis, characterization, in vitro bioactivities, and interaction with SS-DNA
- 作者: Javed F.1, Ali S.1, Shahzadi S.1, Tahir M.2, Tabassum S.3, Khalid N.4
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隶属关系:
- Department of Chemistry
- Department of Physics
- Department of Biotechnology
- Chemistry Division
- 期: 卷 86, 编号 12 (2016)
- 页面: 2768-2776
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/216909
- DOI: https://doi.org/10.1134/S1070363216120380
- ID: 216909
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详细
Organotin(IV) O-butyl carbonodithioates [Me2SnL2], [Bu2SnL2], [Ph2SnL2], [Bu3SnL], and [Ph3SnL], where L = C4H9OCS2–, have been successfully synthesized and characterized by FT-IR, 1H and 13C NMR, and single crystal X-ray analysis. The ligand coordinates to the tin atom via the carbonodithioate group. According to the X-ray diffraction data, the tin atom in [Me2SnL2] has distorted tetrahedral geometry. The synthesized compounds were screened in vitro for antibacterial, antifungal, antileishmanial, cytotoxic, and protein kinase inhibitory activities. The complexes [Bu3SnL] and [Ph3SnL] exhibited the highest anti-leishmanial activity that exceeded the activity of the reference drug amphotericin B, probably by blocking the function of parasitic mitochondria due to which it restricts further growth of the organisms. The ligand and the complexes have been shown to bind to DNA via intercalative interactions resulting in hypochromic effect with a minor red shift as confirmed by UV-Vis spectroscopic studies.
作者简介
F. Javed
Department of Chemistry
Email: drsa54@hotmail.com
巴基斯坦, Islamabad, 45320
S. Ali
Department of Chemistry
编辑信件的主要联系方式.
Email: drsa54@hotmail.com
巴基斯坦, Islamabad, 45320
S. Shahzadi
Department of Chemistry
Email: drsa54@hotmail.com
巴基斯坦, Islamabad, 45320
M. Tahir
Department of Physics
Email: drsa54@hotmail.com
巴基斯坦, Sargodha
S. Tabassum
Department of Biotechnology
Email: drsa54@hotmail.com
巴基斯坦, Islamabad, 45320
N. Khalid
Chemistry Division
Email: drsa54@hotmail.com
巴基斯坦, Nilore, Islamabad