Organotin(IV) O-butyl carbonodithioates: Synthesis, characterization, in vitro bioactivities, and interaction with SS-DNA
- Authors: Javed F.1, Ali S.1, Shahzadi S.1, Tahir M.N.2, Tabassum S.3, Khalid N.4
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Affiliations:
- Department of Chemistry
- Department of Physics
- Department of Biotechnology
- Chemistry Division
- Issue: Vol 86, No 12 (2016)
- Pages: 2768-2776
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/216909
- DOI: https://doi.org/10.1134/S1070363216120380
- ID: 216909
Cite item
Abstract
Organotin(IV) O-butyl carbonodithioates [Me2SnL2], [Bu2SnL2], [Ph2SnL2], [Bu3SnL], and [Ph3SnL], where L = C4H9OCS2–, have been successfully synthesized and characterized by FT-IR, 1H and 13C NMR, and single crystal X-ray analysis. The ligand coordinates to the tin atom via the carbonodithioate group. According to the X-ray diffraction data, the tin atom in [Me2SnL2] has distorted tetrahedral geometry. The synthesized compounds were screened in vitro for antibacterial, antifungal, antileishmanial, cytotoxic, and protein kinase inhibitory activities. The complexes [Bu3SnL] and [Ph3SnL] exhibited the highest anti-leishmanial activity that exceeded the activity of the reference drug amphotericin B, probably by blocking the function of parasitic mitochondria due to which it restricts further growth of the organisms. The ligand and the complexes have been shown to bind to DNA via intercalative interactions resulting in hypochromic effect with a minor red shift as confirmed by UV-Vis spectroscopic studies.
About the authors
F. Javed
Department of Chemistry
Email: drsa54@hotmail.com
Pakistan, Islamabad, 45320
S. Ali
Department of Chemistry
Author for correspondence.
Email: drsa54@hotmail.com
Pakistan, Islamabad, 45320
S. Shahzadi
Department of Chemistry
Email: drsa54@hotmail.com
Pakistan, Islamabad, 45320
M. N. Tahir
Department of Physics
Email: drsa54@hotmail.com
Pakistan, Sargodha
S. Tabassum
Department of Biotechnology
Email: drsa54@hotmail.com
Pakistan, Islamabad, 45320
N. Khalid
Chemistry Division
Email: drsa54@hotmail.com
Pakistan, Nilore, Islamabad