Synthesis of novel 2,4,6-trisubstituted pyrimidine derivatives and their in vitro antimicrobial activity
- 作者: Ashok D.1, Kumar R.2, Mohan Gandhi D.1, Jayashree A.3
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隶属关系:
- Department of Chemistry
- Richmond Vivek Laboratories, Mallapur
- Centre for Chemical Science and Technology
- 期: 卷 86, 编号 6 (2016)
- 页面: 1396-1404
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215389
- DOI: https://doi.org/10.1134/S1070363216060268
- ID: 215389
如何引用文章
详细
A series of novel pyrimidines (6a–6i) has been synthesized from corresponding chalcones and isonicotinimidamide.HCl in the presence of potassium carbonate involving Michael addition followed by cycloaddition. All newly synthesised chalcones and pyrimidines were screened for in vitro antimicrobial activity against various Gram positive, Gram negative bacterial and fungal strains. Most of compounds displayed high antimicrobial activity compared to standard drugs Penicillin, Streptomycin and Ampothericin-B.
作者简介
D. Ashok
Department of Chemistry
编辑信件的主要联系方式.
Email: ashokdou@gmail.com
印度, Hyderabad, 500007
R. Kumar
Richmond Vivek Laboratories, Mallapur
Email: ashokdou@gmail.com
印度, Hyderabad, 500076
D. Mohan Gandhi
Department of Chemistry
Email: ashokdou@gmail.com
印度, Hyderabad, 500007
A. Jayashree
Centre for Chemical Science and Technology
Email: ashokdou@gmail.com
印度, Hyderabad, 500085