Synthesis of novel 2,4,6-trisubstituted pyrimidine derivatives and their in vitro antimicrobial activity
- Авторы: Ashok D.1, Kumar R.2, Mohan Gandhi D.1, Jayashree A.3
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Учреждения:
- Department of Chemistry
- Richmond Vivek Laboratories, Mallapur
- Centre for Chemical Science and Technology
- Выпуск: Том 86, № 6 (2016)
- Страницы: 1396-1404
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215389
- DOI: https://doi.org/10.1134/S1070363216060268
- ID: 215389
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Аннотация
A series of novel pyrimidines (6a–6i) has been synthesized from corresponding chalcones and isonicotinimidamide.HCl in the presence of potassium carbonate involving Michael addition followed by cycloaddition. All newly synthesised chalcones and pyrimidines were screened for in vitro antimicrobial activity against various Gram positive, Gram negative bacterial and fungal strains. Most of compounds displayed high antimicrobial activity compared to standard drugs Penicillin, Streptomycin and Ampothericin-B.
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Об авторах
D. Ashok
Department of Chemistry
Автор, ответственный за переписку.
Email: ashokdou@gmail.com
Индия, Hyderabad, 500007
R. Kumar
Richmond Vivek Laboratories, Mallapur
Email: ashokdou@gmail.com
Индия, Hyderabad, 500076
D. Mohan Gandhi
Department of Chemistry
Email: ashokdou@gmail.com
Индия, Hyderabad, 500007
A. Jayashree
Centre for Chemical Science and Technology
Email: ashokdou@gmail.com
Индия, Hyderabad, 500085
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