Synthesis of novel 2,4,6-trisubstituted pyrimidine derivatives and their in vitro antimicrobial activity
- Authors: Ashok D.1, Kumar R.S.2, Mohan Gandhi D.1, Jayashree A.3
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Affiliations:
- Department of Chemistry
- Richmond Vivek Laboratories, Mallapur
- Centre for Chemical Science and Technology
- Issue: Vol 86, No 6 (2016)
- Pages: 1396-1404
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215389
- DOI: https://doi.org/10.1134/S1070363216060268
- ID: 215389
Cite item
Abstract
A series of novel pyrimidines (6a–6i) has been synthesized from corresponding chalcones and isonicotinimidamide.HCl in the presence of potassium carbonate involving Michael addition followed by cycloaddition. All newly synthesised chalcones and pyrimidines were screened for in vitro antimicrobial activity against various Gram positive, Gram negative bacterial and fungal strains. Most of compounds displayed high antimicrobial activity compared to standard drugs Penicillin, Streptomycin and Ampothericin-B.
Keywords
About the authors
D. Ashok
Department of Chemistry
Author for correspondence.
Email: ashokdou@gmail.com
India, Hyderabad, 500007
R. Suneel Kumar
Richmond Vivek Laboratories, Mallapur
Email: ashokdou@gmail.com
India, Hyderabad, 500076
D. Mohan Gandhi
Department of Chemistry
Email: ashokdou@gmail.com
India, Hyderabad, 500007
A. Jayashree
Centre for Chemical Science and Technology
Email: ashokdou@gmail.com
India, Hyderabad, 500085
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