Synthesis and characterization of new acyclic nucleosides analogues derived from 2-phenyl quinoline candidates


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详细

Reaction of 4-substituted quinoline hydrazide with some aldohexoses and aldopentoses gave a series of new N-β-glycosides. The following cyclization of N-β-glycosides with acetic anhydride led to O-acetyl-[5-(2-phenylquinolin-4-yl)-1,3,4-oxadiazol-2-yl]-D-glycosides. Structure of the newly synthesized products was elucidated by chemical and spectroscopic methods.

作者简介

N. Khalifa

Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy; Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division

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Email: nagykhalifa@hotmail.com
沙特阿拉伯, Riyadh, 11451; Dokki, Cairo, 12622

M. Al-Omar

Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy; Pharmaceutical Chemistry Department, College of Pharmacy

Email: nagykhalifa@hotmail.com
沙特阿拉伯, Riyadh, 11451; Riyadh, 11451

A. Amr

Pharmaceutical Chemistry Department, College of Pharmacy; Applied Organic Chemistry Department

Email: nagykhalifa@hotmail.com
沙特阿拉伯, Riyadh, 11451; Dokki, Cairo, 12622


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