Email this article Synthesis and characterization of new acyclic nucleosides analogues derived from 2-phenyl quinoline candidates
- Authors: Khalifa N.M.1,2, Al-Omar M.A.1,3, Amr A.E.3,4
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Affiliations:
- Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy
- Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division
- Pharmaceutical Chemistry Department, College of Pharmacy
- Applied Organic Chemistry Department
- Issue: Vol 86, No 5 (2016)
- Pages: 1115-1119
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215000
- DOI: https://doi.org/10.1134/S1070363216050224
- ID: 215000
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Abstract
Reaction of 4-substituted quinoline hydrazide with some aldohexoses and aldopentoses gave a series of new N-β-glycosides. The following cyclization of N-β-glycosides with acetic anhydride led to O-acetyl-[5-(2-phenylquinolin-4-yl)-1,3,4-oxadiazol-2-yl]-D-glycosides. Structure of the newly synthesized products was elucidated by chemical and spectroscopic methods.
About the authors
N. M. Khalifa
Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy; Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division
Author for correspondence.
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622
M. A. Al-Omar
Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy; Pharmaceutical Chemistry Department, College of Pharmacy
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Riyadh, 11451
A. E. Amr
Pharmaceutical Chemistry Department, College of Pharmacy; Applied Organic Chemistry Department
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622
