Synthesis and antiproliferative activity of 6,7-aryl/hetaryl coumarins
- 作者: Jayaprakash Rao Y.1, Yadaiah goud E.1, Hemasri Y.2, Jain N.3, Gabriella S.3
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隶属关系:
- Department of Chemistry
- Department of Chemistry, Nizam College
- Center for Chemical Biology
- 期: 卷 86, 编号 1 (2016)
- 页面: 184-189
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/213601
- DOI: https://doi.org/10.1134/S1070363216010291
- ID: 213601
如何引用文章
详细
Two different series of novel analogs of 6,7-aryl/hetaryl coumarins 4a–4h and 8i–8l have been synthesized by using Suzuki–Miyara cross coupling reaction from 4-methyl-2-oxo-2H-chromen-7-yl trifluoro-methanesulfonate and 4-methyl-2-oxo-2H-chromen-6-yl trifluoromethanesulfonate in high yields (70–90%). All synthesized compounds were elucidated by means of IR, 1H NMR, 13C NMR, and MS spectra. The synthesized compounds were tested for antiproliferative activity against different human cancer cell lines (SiHa, MDAMB-231, and PANC-1) and some of products demonstrated the distinctive effect.
作者简介
Y. Jayaprakash Rao
Department of Chemistry; Department of Chemistry
Email: erukalayadaiahgoud@gmail.com
印度, Hyderabad, Telangana, 500007; Nizamabad, 503322
E. Yadaiah goud
Department of Chemistry
编辑信件的主要联系方式.
Email: erukalayadaiahgoud@gmail.com
印度, Hyderabad, Telangana, 500007
Y. Hemasri
Department of Chemistry, Nizam College
Email: erukalayadaiahgoud@gmail.com
印度, Osmania, 500001
Nishant Jain
Center for Chemical Biology
Email: erukalayadaiahgoud@gmail.com
印度, Hyderabad, 500007
Srujana Gabriella
Center for Chemical Biology
Email: erukalayadaiahgoud@gmail.com
印度, Hyderabad, 500007