Synthesis and antiproliferative activity of 6,7-aryl/hetaryl coumarins
- Authors: Jayaprakash Rao Y.1, Yadaiah goud E.1, Hemasri Y.2, Jain N.3, Gabriella S.3
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Affiliations:
- Department of Chemistry
- Department of Chemistry, Nizam College
- Center for Chemical Biology
- Issue: Vol 86, No 1 (2016)
- Pages: 184-189
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/213601
- DOI: https://doi.org/10.1134/S1070363216010291
- ID: 213601
Cite item
Abstract
Two different series of novel analogs of 6,7-aryl/hetaryl coumarins 4a–4h and 8i–8l have been synthesized by using Suzuki–Miyara cross coupling reaction from 4-methyl-2-oxo-2H-chromen-7-yl trifluoro-methanesulfonate and 4-methyl-2-oxo-2H-chromen-6-yl trifluoromethanesulfonate in high yields (70–90%). All synthesized compounds were elucidated by means of IR, 1H NMR, 13C NMR, and MS spectra. The synthesized compounds were tested for antiproliferative activity against different human cancer cell lines (SiHa, MDAMB-231, and PANC-1) and some of products demonstrated the distinctive effect.
About the authors
Y. Jayaprakash Rao
Department of Chemistry; Department of Chemistry
Email: erukalayadaiahgoud@gmail.com
India, Hyderabad, Telangana, 500007; Nizamabad, 503322
E. Yadaiah goud
Department of Chemistry
Author for correspondence.
Email: erukalayadaiahgoud@gmail.com
India, Hyderabad, Telangana, 500007
Y. Hemasri
Department of Chemistry, Nizam College
Email: erukalayadaiahgoud@gmail.com
India, Osmania, 500001
Nishant Jain
Center for Chemical Biology
Email: erukalayadaiahgoud@gmail.com
India, Hyderabad, 500007
Srujana Gabriella
Center for Chemical Biology
Email: erukalayadaiahgoud@gmail.com
India, Hyderabad, 500007