Synthesis and antiproliferative activity of 6,7-aryl/hetaryl coumarins
- Авторы: Jayaprakash Rao Y.1, Yadaiah goud E.1, Hemasri Y.2, Jain N.3, Gabriella S.3
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Учреждения:
- Department of Chemistry
- Department of Chemistry, Nizam College
- Center for Chemical Biology
- Выпуск: Том 86, № 1 (2016)
- Страницы: 184-189
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/213601
- DOI: https://doi.org/10.1134/S1070363216010291
- ID: 213601
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Аннотация
Two different series of novel analogs of 6,7-aryl/hetaryl coumarins 4a–4h and 8i–8l have been synthesized by using Suzuki–Miyara cross coupling reaction from 4-methyl-2-oxo-2H-chromen-7-yl trifluoro-methanesulfonate and 4-methyl-2-oxo-2H-chromen-6-yl trifluoromethanesulfonate in high yields (70–90%). All synthesized compounds were elucidated by means of IR, 1H NMR, 13C NMR, and MS spectra. The synthesized compounds were tested for antiproliferative activity against different human cancer cell lines (SiHa, MDAMB-231, and PANC-1) and some of products demonstrated the distinctive effect.
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Об авторах
Y. Jayaprakash Rao
Department of Chemistry; Department of Chemistry
Email: erukalayadaiahgoud@gmail.com
Индия, Hyderabad, Telangana, 500007; Nizamabad, 503322
E. Yadaiah goud
Department of Chemistry
Автор, ответственный за переписку.
Email: erukalayadaiahgoud@gmail.com
Индия, Hyderabad, Telangana, 500007
Y. Hemasri
Department of Chemistry, Nizam College
Email: erukalayadaiahgoud@gmail.com
Индия, Osmania, 500001
Nishant Jain
Center for Chemical Biology
Email: erukalayadaiahgoud@gmail.com
Индия, Hyderabad, 500007
Srujana Gabriella
Center for Chemical Biology
Email: erukalayadaiahgoud@gmail.com
Индия, Hyderabad, 500007
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